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      <image:title>PostDocs - Dr. Meng Wang</image:title>
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      <image:title>2016 - Tao, J., Wu, H., Coronado, AA., de Laittre E, Osterweil, EK., Zhang, Y., Bear, MF. (2016) Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome. J Neuroscience, 36(47):11946-11958.</image:title>
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      <image:title>2016 - Kim, M., Lu, F., and Zhang, Y. (2016). Loss of HDAC-mediated repression and gain of NF-kB-mediated activation underlie cytokine induction in ARID1A and PIK3CA mutations-driven ovarian cancer. Cell Reports, 17(1):275-88.</image:title>
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      <image:title>2016 - Wu, H., Wu, X., Zhang, Y. (2016). Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq. Nature Protocols 11(6):1081-1100.</image:title>
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      <image:title>2016 - Lu, F., Liu, YT., Inoue, A., Suzuki, T., Zhao, K., Zhang, Y. (2016). Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development. Cell 165(6):1375-1388.</image:title>
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    <lastmod>2023-08-14</lastmod>
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    <loc>https://www.zhanglab.tch.harvard.edu/the-pi</loc>
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    <lastmod>2017-08-01</lastmod>
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      <image:title>Alumni - Dr. Hengbin Wang</image:title>
      <image:caption>Dr Hengbin Wang Associate Professor University of Alabama</image:caption>
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    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499873354579-K17VKL4U4G1N7OUMHLHN/JiaFang.jpg</image:loc>
      <image:title>Alumni - Dr. Jia Fang</image:title>
      <image:caption>Dr. Jia Fang Assistant Professor University of South Florida</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1497983707612-L4J6DS3HMUWX5J0YC3M8/cyrussmall.jpg</image:loc>
      <image:title>Alumni - Dr. Cyrus Martin</image:title>
      <image:caption>Dr. Cyrus Martin Senior Editor Current Biology - Cell Press</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499965007660-KISHP7O8Q4I56BIE4DTC/yuichismall.jpg</image:loc>
      <image:title>Alumni - Dr. Yuichi Tsukada</image:title>
      <image:caption>Dr. Yuichi Tsukada</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499875311183-YK7BPKLM49UY6CE87PU9/RobKlose</image:loc>
      <image:title>Alumni - Dr. Robert Klose</image:title>
      <image:caption>Dr Robert Klose Professor University of Oxford</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1500914010331-UVE3RK2RZE4ZBASN4TS1/kenichismall.jpg</image:loc>
      <image:title>Alumni - Dr. Kenichi Yamane</image:title>
      <image:caption>Dr. Kenichi Yamane Research Fellow NIH</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501601226828-35FR7LSEU74HSVV2QZDM/keisukesmall.jpg</image:loc>
      <image:title>Alumni - Dr. Keisuke Tateishi</image:title>
      <image:caption>Dr. Keisuke Tateishi Associate Professor University of Tokyo</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1500914183719-34W82CVEFPUAFLJR6TSN/yukiokada</image:loc>
      <image:title>Alumni - Dr. Yuki Okada</image:title>
      <image:caption>Professor University of Tokyo</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499875477065-9OX253T2TGPBFQC6J5GG/Kaismall.jpg</image:loc>
      <image:title>Alumni - Dr. Kai Xia</image:title>
      <image:caption>Katherine Sato</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499964538252-KVI1NBMHG5B46PMM08S0/naralee</image:loc>
      <image:title>Alumni - Dr. Nara Lee</image:title>
      <image:caption>Kimberly Johnson</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1500914286436-38WP62RRNJ6OB04J2C6B/image-asset.jpeg</image:loc>
      <image:title>Alumni - Dr. Chuan Wei Jang</image:title>
      <image:caption>Rose Jenkins</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501604776317-70NODF8E1W91L04R20SW/yunfang</image:loc>
      <image:title>Alumni - Dr. Yunfang Wang</image:title>
      <image:caption>Professor Beijing Institute of Transfusion Medicine</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499874596006-5SWPBUX3LYZSV0BT6B2K/Itosmall.jpg</image:loc>
      <image:title>Alumni - Dr. Shinsuke Ito</image:title>
      <image:caption>Research Scientist RIKEN Center for Integrative Medical Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501604941409-V5SUETW9AMYYKGKOOA7Y/ma.JPG</image:loc>
      <image:title>Alumni - Dr. Ma Wan</image:title>
      <image:caption>Rose Sung</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605169691-6YINNQHLM27QUWCBB7XU/anadalessio</image:loc>
      <image:title>Alumni - Dr. Ana D'Alessio</image:title>
      <image:caption>Director of Research Development-Biology Cellino</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605184666-H6NO9ASWWNVN9AE4F4Z3/huijue</image:loc>
      <image:title>Alumni - Dr. Huijue Jia</image:title>
      <image:caption>Vice Dean &amp; Chief Scientist BGI - Shenzen</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605405674-OXDKZ7MBIDMGBYUHZ79S/olena</image:loc>
      <image:title>Alumni - Dr. Olena Taranova</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605375719-9ZM5KH0AXIXQWPPHNAUT/fujunglin</image:loc>
      <image:title>Alumni - Dr. Fu-Jung Lin</image:title>
      <image:caption>Associate Professor National Taiwan University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605336956-UN577BWUFVYULEFTNXIX/kwonho</image:loc>
      <image:title>Alumni - Dr. Kwon-Ho Hong</image:title>
      <image:caption>Associate Professor Konkuk University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605294222-ENJR08OODUCNKZBMVLY8/xiangma</image:loc>
      <image:title>Alumni - Dr. Xiang Ma</image:title>
      <image:caption>Post-Doc Harvard Medical School</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1515190457482-YKLFXIG40NVAOCK47BAA/jin+he.jpg</image:loc>
      <image:title>Alumni - Dr. Jin He</image:title>
      <image:caption>Assistant Professor Michigan State University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499874402011-ZOA0L6FAKHH8Q85YI83U/shogomatoba</image:loc>
      <image:title>Alumni - Dr. Shogo Matoba</image:title>
      <image:caption>Sr Research Scientist RIKEN Bioresource Center</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605615597-YUOC8DIREDLH1M50Q6IO/weijiang</image:loc>
      <image:title>Alumni - Dr. Wei Jiang</image:title>
      <image:caption>Professor Wuhan University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1500913418686-9BEW6LBRURM1YX6P4N08/shinpei</image:loc>
      <image:title>Alumni - Dr. Shinpei Yamaguchi</image:title>
      <image:caption>Associate Professor Toho University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499874204282-P8KTE5E6CQ6XM6VJMO2O/LiShen</image:loc>
      <image:title>Alumni - Dr. Li Shen</image:title>
      <image:caption>Professor Zhejiang University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499873827608-3W0FS1M535P4BPL7C8UP/kumikoiwabuchi</image:loc>
      <image:title>Alumni - Dr. Kumiko Iwabuchi</image:title>
      <image:caption>Scientist St. Jude Children's Research Hospital.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605639951-3JLAZBSG651DEPFNPRRB/yuting</image:loc>
      <image:title>Alumni - Dr. Yuting Liu</image:title>
      <image:caption>Head of Data Science CAMP4 Therapeutics</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499875941579-NNVPMXYW8XRXOQ33ZS7T/haowu</image:loc>
      <image:title>Alumni - Dr. Hao Wu</image:title>
      <image:caption>Associate Professor University of Pennsylvania</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499879322682-QV6H6RMQVVACW6NYHYCK/yuwang</image:loc>
      <image:title>Alumni - Dr. Yu Wang</image:title>
      <image:caption>Principal Scientist Voyager Therapeutics</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501605512400-PCOR4RZX2WBIS2LVZBSN/image-asset.jpeg</image:loc>
      <image:title>Alumni - Dr. Minchul Kim</image:title>
      <image:caption>Group Leader Institute of Genetics and Molecular and Cellular Biology</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1497984225941-KTT6P1674JL081Z9S9MQ/tsukasa</image:loc>
      <image:title>Alumni - Dr. Tsukasa Suzuki</image:title>
      <image:caption>Researcher Kyowa-Hakko Kirin</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499875836678-1YP6AE96TV4NPNSBIH4F/FalongLu</image:loc>
      <image:title>Alumni - Dr. Falong Lu</image:title>
      <image:caption>Professor Institute of Genetics Chinese Academy of Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1520001651332-QYW0VGQAI7QXBJB1BEV7/azusa3.jpg</image:loc>
      <image:title>Alumni - Dr. Azusa Inoue</image:title>
      <image:caption>Team Leader RIKEN IMS</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1537556460359-26HYQZIDX0NH4VP7DDOJ/Picture1.png</image:loc>
      <image:title>Alumni - Dr. Lan Jiang</image:title>
      <image:caption>Dr. Lan Jiang Beijing Institute of Genomics Chinese Academy of Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1573565861043-BO5ZNUYX376V2DS5FPZT/Luis%252BTuesta%252Bbw.jpg</image:loc>
      <image:title>Alumni - Dr. Luis Tuesta</image:title>
      <image:caption>Assistant Professor University of Miami Miller School of Medicine</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546915123689-JBJVYLFJNU9VDQ3W4UD7/Wenqiang.jpg</image:loc>
      <image:title>Alumni - Dr. Wenqiang Chen</image:title>
      <image:caption>Dr. Wenqiang Chen Joslin Diabetes Center</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1600015658441-OL1HOIQP9FYMMWWJRP31/Zhenfei.jpg</image:loc>
      <image:title>Alumni - Dr. Zhenfei Xie</image:title>
      <image:caption>Assistant Professor Wuhan University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1600016075604-5SV7CMH5DAY8IZTT4NB0/Nadhir.jpg</image:loc>
      <image:title>Alumni - Dr. Nadhir Djekidel</image:title>
      <image:caption>Staff Scientist Sidra Medicine</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546917576526-YNWQ5U9Y5YK9JG2VBV4Q/Xudong.jpg</image:loc>
      <image:title>Alumni - Dr. Xudong Fu</image:title>
      <image:caption>Assistant Professor Zhejiang University Medical Center</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/48aa9f31-6044-44d8-ae11-dcf9e64fd578/Screen+Shot+2021-11-02+at+11.23.58+AM.png</image:loc>
      <image:title>Alumni - Dr. Xiao Han</image:title>
      <image:caption>Senior Scientist Myrobalan Therapeutics</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546912713357-BCPOPF0YT8JKI31ROKX3/Renchao.jpg</image:loc>
      <image:title>Alumni - Dr. Renchao Chen</image:title>
      <image:caption>Application Scientist, Neuroscience Lead Vizgen</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546916899518-K0T1EMB3LSUZYNWOVSEN/Lifeng.jpg</image:loc>
      <image:title>Alumni - Dr. Lifeng Yuan</image:title>
      <image:caption>Scientist II Parabilis Medicines</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546915525322-N0BNP42K9VCF7YLMFXE4/Zhiyuan.jpg</image:loc>
      <image:title>Alumni - Dr. Zhiyuan Chen</image:title>
      <image:caption>Assistant Professor Cincinnati Children’s Hospital Medical Center</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546917834382-AJR5S51NISTOUGSQ0UY2/Yuangao.jpg</image:loc>
      <image:title>Alumni - Dr. Yuangao Wang</image:title>
      <image:caption>Assistant Professor Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546915402244-ERYUSZ74285B8YY12DD6/Untitled+6.jpg</image:loc>
      <image:title>Alumni - Dr. Chunxia Zhang</image:title>
      <image:caption>Assistant Professor Institute of Genetics and Developmental Biology, Chinese Academy of Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546916749626-FCJJKY9VVSRFTDFKEXYK/Wenhao.jpg</image:loc>
      <image:title>Alumni - Dr. Wenhao Zhang</image:title>
      <image:caption>Senior Scientist AstraZeneca</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1556761449996-B39EU9WZHVI33EXKRENZ/Zhendong.jpg</image:loc>
      <image:title>Alumni - Dr. Zhengdong Zhao</image:title>
      <image:caption>Assistant Professor Songjiang Research Institute, Shanghai Jiaotong University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/ce822fb2-0d33-4e4f-a335-712ed1083a96/hongjiao+cropped.jpg</image:loc>
      <image:title>Alumni - Dr. Hongjiao Xu</image:title>
      <image:caption>Senior Editor Cell Press</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1556651787788-KY6XTU2XMKHEVJQQ374L/Takashi.jpg</image:loc>
      <image:title>Alumni - Dr. Takashi Seino</image:title>
      <image:caption>Assistant Professor Keio University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/189c9686-b322-4fc6-9007-0f7f8e4fc78f/chao+photo+cropped.jpg</image:loc>
      <image:title>Alumni - Dr. Chao Zhang</image:title>
      <image:caption>Assistant Professor Kunming Institute of Zoology, Chinese Academy of Sciences</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1408516d-430b-42c2-82ed-5b1ce8f3ea2e/Ruiqi+Square.jpg</image:loc>
      <image:title>Alumni - Dr. Ruiqi Ge</image:title>
      <image:caption>Postdoctoral Fellow Boston Children’s Hospital</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/13a70f40-aeef-4c65-a458-a889166ffbef/Ren_lab+website.jpg</image:loc>
      <image:title>Alumni - Dr. Xiangle Ren</image:title>
      <image:caption>Postdoctoral Fellow Massachusetts General Hospital</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/749ee456-ea98-47d3-8f61-509234e7c039/Ying+Website+Photo.jpg</image:loc>
      <image:title>Alumni - Dr. Ying Wang</image:title>
      <image:caption>Associate Professor Qingdao University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1505249466549-SPM2PO317RKSKCUWBKE0/aritrab.jpg</image:loc>
      <image:title>Alumni - Dr. Aritra Bhattacherjee</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1620151621854-7FHLRXUD4M8XGYMSVDTW/Yota_Hagihara.jpg</image:loc>
      <image:title>Alumni - Dr. Yota Hagihara</image:title>
      <image:caption>Assistant Professor Kyushu University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499874707457-DNKZRBYVL1ZC442LI9HT/qinfeng</image:loc>
      <image:title>Alumni - Dr. Qin Feng</image:title>
      <image:caption>Associate Professor University of Houston</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501608136975-V2IU70SH2MQNQSYQQNAN/Dr.+Ru+Cao</image:loc>
      <image:title>Alumni - Dr. Ru Cao</image:title>
      <image:caption>Senior Manager Thermo Fisher Scientific</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499873223069-HZKVLMTR5QSPVBZ62BVW/EricKallin</image:loc>
      <image:title>Alumni - Dr. Eric Kallin</image:title>
      <image:caption>Vice President, Brand Strategy BGB Group</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501608176923-FOLV2JQXUHGWHLV9VEO4/image-asset.jpeg</image:loc>
      <image:title>Alumni - Dr. Anh Nguyen</image:title>
      <image:caption>Research Project Manager Duke University School of Medicine</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1500913502473-JVR0URPM1L6DEF1LNQGS/image-asset.jpeg</image:loc>
      <image:title>Alumni - Dr. Susan Wu</image:title>
      <image:caption>Senior Director, Project Management Celsius Therapeutics</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501608194908-8FOZYOWUTFQ5PIZE4YGE/image-asset.jpeg</image:loc>
      <image:title>Alumni - Dr. Gaoyang Liang</image:title>
      <image:caption>Staff Scientist Salk Institute</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1602612656677-27YQK1TALMHNG2MGD6UC/XiaojiWu.jpg</image:loc>
      <image:title>Alumni - Dr. Xiaoji Wu</image:title>
      <image:caption>Senior Manager Bain &amp; Company</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1602612877234-0QO372ZKM73H6ORJKNGK/20180525%2BPhoto%2BHiro.jpg</image:loc>
      <image:title>Alumni - Dr. Hiroyuki Kato</image:title>
      <image:caption>Postdoctoral Fellow Massachusetts General Hospital</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1602613973398-ZO490SH5RE7T070QHUGM/Cathy.jpg</image:loc>
      <image:title>Alumni - Cathy Li</image:title>
      <image:caption>Postdoctoral Fellow Tsinghua University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/563adcfa-2e83-4304-a970-b1cd0b7b3ef1/madhu+photo.jpeg</image:loc>
      <image:title>Alumni - Madhulika Badri</image:title>
      <image:caption>Medical Student Drexel University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/168a929f-5b89-442f-94bf-2b76c603d4cd/Jiayi+Li+website+photo.jpg</image:loc>
      <image:title>Alumni - Jiayi Li</image:title>
      <image:caption>Master’s Student Cornell University</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/a488aad4-e0c3-46c0-9416-7b086bae5fdc/Tran+Photo.jpeg</image:loc>
      <image:title>Alumni - Tran Van</image:title>
      <image:caption>Research Assistant Brigham and Women’s Hospital</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/090ce447-b628-4803-b112-875a5300278f/Jim.jpg</image:loc>
      <image:title>Alumni - Jim Lin</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/e7dd509d-3d7f-43d0-b788-c28644ea5d29/Michelle+Li+-+Website+Photo.jpg</image:loc>
      <image:title>Alumni - Michelle Li</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/a3d5fa0a-d95c-4b19-bf36-071a9a41c28a/vicki.jpg</image:loc>
      <image:title>Alumni - Victoria Chin</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/71ced6fd-a916-4f19-a9bd-6ba9d387494d/Jennifer+Ballew.jpg</image:loc>
      <image:title>Alumni - Jennifer Ballew</image:title>
      <image:caption>Green Labs Program Coordinator at Massachusetts Institute of Technology</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1546918395660-BV4GDCOBCSN30B5WO7B7/Kate.jpg</image:loc>
      <image:title>Alumni - Kate Simpson</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1560544595897-JYH0GMUOQ133DEN9S67K/Qiangzong.jpg</image:loc>
      <image:title>Alumni - Qianzong Yin</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1551288233187-2WBCEKSX1NIX3ELD4XD7/Qian.png</image:loc>
      <image:title>Alumni - Qian Zhang</image:title>
      <image:caption>Qian Zhang</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1563899086892-N1OM4QKB7TMKI14VKX38/Amanda.jpg</image:loc>
      <image:title>Alumni - Amanda Liefeld</image:title>
      <image:caption>Amanda Liefeld</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/new-page-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-20</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643173990-S5N1Y3E4Z6UY367TH9I0/image-asset.png</image:loc>
      <image:title>2015 - Jiang, H., Xu, Z., Zhong, P., Ren, Y., Liang, G., Schilling, H., Hu, Z., Zhang, Y., Wang, X., Chen, S., Yan, Z., Feng, J. (2015). Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nature Communications 6:10100</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643193344-Z1SESR8ESO27I8ZGD8OL/image-asset.png</image:loc>
      <image:title>2015 - Wu, H. and Zhang, Y. (2015). Charting oxidized methylcytosines at base resolution. Nat Mol Struct Bio 22(9):656-61</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643227160-W8Y9CPEEW4F68ZDVV45C/image-asset.png</image:loc>
      <image:title>2015 - Chung, Y.G., Matoba, S., Liu, Y., Cha, K.Y., Lee, D.R., and Zhang, Y. (2015). Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells. Cell Stem Cell, 17(6):758-66.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643255272-18V0OR58HSHMVFAOJZYI/image-asset.png</image:loc>
      <image:title>2015 - Inoue, A., Shen, L., Matoba, S., and Zhang, Y. (2015). Haploinsufficiency, but Not Defective Paternal 5mC Oxidation, Accounts for the Developmental Defects of Maternal Tet3 Knockouts. Cell Reports 10(4), 463–470.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643272126-1226ZX5XQC3K0C1SRGB1/image-asset.png</image:loc>
      <image:title>2015 - Jiang, W., Liu, Y., Liu, R., Zhang, K., Zhang, Y. (2015). The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression. Cell Reports 11(1),137-148</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643297741-EZ4YCL1CFPI89LJQ3DJS/image-asset.png</image:loc>
      <image:title>2015 - Lu, F., and Zhang, Y. (2015). Cell totipotency: molecular features, induction, and maintenance. National Science Review 2(2), 217-225</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2014</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-20</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643471759-2YS9NMAOL3ZKIBIQQDAI/image-asset.png</image:loc>
      <image:title>2014 - Wang, Y., and Zhang, Y. (2014). Regulation of TET Protein Stability by Calpains. Cell Reports 6(2):278-284.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643481125-WHC1YCVUKQJD84X7XOBD/image-asset.png</image:loc>
      <image:title>2014 - Wu, H., and Zhang, Y. (2014). Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions. Cell 156(1-2):45-68.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643490610-XVHA26CGCMUGVUOTIOOG/image-asset.png</image:loc>
      <image:title>2014 - Tuesta, L.M., and Zhang, Y. (2014). Mechanisms of epigenetic memory and addiction. EMBO J. 33(10):1091-1103</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643544113-ACQYXRDDE3BEO2HKXSXP/image-asset.png</image:loc>
      <image:title>2014 - Li, X., Wei, W., Zhao, Q.Y., Widagdo, J., Baker-Andresen, D., Flavell, C.R., D'Alessio, A., Zhang, Y., and Bredy, T.W. (2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. PNAS 111(19):7120–7125.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643555277-D9671YULXJRXRV1NE7F8/image-asset.png</image:loc>
      <image:title>2014 - Inoue, A., and Zhang, Y. (2014). Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes. Nature Structural &amp; Molecular Biology. 21(7):609–616.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643593514-CBCWIBJQDUXY98RRL6LQ/image-asset.png</image:loc>
      <image:title>2014 - Shen, L., Song, C.-X., He, C., and Zhang, Y. (2014). Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation. Annu. Rev. Biochem. 83, 585–614.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643631326-OW0EMHZ7RBXXWC33IMS6/image-asset.png</image:loc>
      <image:title>2014 - Inoue, A., Sunaga, K., Aoki, F., and Zhang, Y. (2014). siRNA-mediated depletion of stable proteins in mouse oocytes. Protocol Exchange. Published online 21 July 2014</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643639558-ZAFDRZ6CLI7G3MAVMLPF/image-asset.png</image:loc>
      <image:title>2014 - Lu, F., Liu, Y., Jiang, L., Yamaguchi, S., and Zhang, Y. (2014). Role of Tet proteins in enhancer activity and telomere elongation. Genes Dev. 28(19):2103-2119.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643647514-DZKUO7RW9AZRA01X47ZQ/image-asset.png</image:loc>
      <image:title>2014 - Shen, L., Inoue, A., He, J., Liu, Y., Lu, F., and Zhang Y. (2014). Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes. Cell Stem Cell. 15(4):459–470.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643693230-FPBICIWKLAVMJILY4DQJ/image-asset.png</image:loc>
      <image:title>2014 - Matoba, S., Liu, Y., Lu, F., Iwabuchi, K.A., Shen, L., Inoue, A., and Zhang, Y. (2014). Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation. Cell 159(4):884–895.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499643703669-WT6822Q1E58W2EZSMUDK/image-asset.png</image:loc>
      <image:title>2014 - Wu, H., Wu, X., Shen, L., and Zhang, Y. (2014). Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing. Nat Biotechnol. 32(12):1231–1240.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2013</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-20</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653743394-OOS6R9COR5NXXA2I1KWP/image-asset.png</image:loc>
      <image:title>2013 - Liang, G., and Zhang, Y. (2013). Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res.23(1),49-69.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653808330-LWU4OGUIIB1RXBPG9DPN/image-asset.png</image:loc>
      <image:title>2013 - Jiang, W., Wang, J., and Zhang, Y. (2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Res. 23(1):122-130.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653837674-F6FQFWX46UDAAMHRNUZI/image-asset.png</image:loc>
      <image:title>2013 - Yamaguchi, S., Hong, K., Liu, R., Inoue, A., Shen, L., Zhang, K., and Zhang, Y. (2013). Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming. Cell Res. 23(3):329-339.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653866793-7F4G5XWLIVL8U8APDOE2/image-asset.png</image:loc>
      <image:title>2013 - He, J., Shen, L., Wan, M., Taranova, O., Wu, H., and Zhang, Y. (2013). Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol. 15(4):373–384.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653905395-W72Y0994LW9DTO9SBNFV/image-asset.png</image:loc>
      <image:title>2013 - Shen, L., Zhang, Y. (2013). 5-Hydroxymethylcytosine: generation, fate, and genomic distribution. Current Opinion in Cell Biology 25(3):289–296.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653925549-A2WU86TIQRE1G3OQF226/image-asset.png</image:loc>
      <image:title>2013 - Shen, L., Wu, H., Diep, D., Yamaguchi, S., D'Alessio, A., Fung, H., Zhang, K., and Zhang, Y. (2013). Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 153(3):692–706.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499653953317-J11H6CHGDSH5Z1S1CK8C/image-asset.png</image:loc>
      <image:title>2013 - Lin, F., Shen, L., Jang, C., Falnes, P., and Zhang, Y. (2013) Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. PLoS Genetics 9(5):e1003516.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654173573-7QN661P4R3Z9PHP2Z2FC/image-asset.png</image:loc>
      <image:title>2013 - Jiang, W., Zhang, D., Bursac, N., Zhang, Y. (2013) WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1(1):46-52.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654203944-X0HF4J1MNTMNOPSWINV1/image-asset.png</image:loc>
      <image:title>2013 - Liang, G., Zhang, Y. (2013) Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application. Cell Stem Cell 13(2):149-59.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654227862-ZBN65CK6BU334EK5E247/image-asset.png</image:loc>
      <image:title>2013 - Ran, F.A., Hsu, P.D., Lin, C.Y., Gootenberg, J.S., Konermann, S., Trevino, A.E., Scott, D.A., Inoue, A., Matoba, S., Zhang, Y., Zhang, F. (2013). Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell 154(6):1380–1389.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654260128-SWTPLX867GB5C5WOR30I/image-asset.png</image:loc>
      <image:title>2013 - Cheng, J., Guo, S., Chen, S., Mastriano, S. J., Liu, C., D’Alessio, A. C., et al. (2013). An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. Cell Reports 5(2):471-481.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654293082-PZ3S3ZWMN1MO354KBCCI/image-asset.png</image:loc>
      <image:title>2013 - Kohli, R.M., Zhang, Y. (2013) TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502(7472):472–479.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499654343686-HKPZK7GALIE8Y67ZQ8X8/image-asset.png</image:loc>
      <image:title>2013 - Yamaguchi, S., Shen, L., Liu, Y., Sendler, D., and Zhang, Y. (2013). Role of Tet1 in genomic imprinting erasure. Nature 504(7480):460-464.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2012</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-20</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693031738-HSHJR2CQ18ERJGR31F3Z/image-asset.png</image:loc>
      <image:title>2012 - Shen, L., Zhang, Y. (2012) Enzymatic Analysis of the Tet proteins. Methods Enzymol. 512:93-105.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693050444-VL3KKALO6CBP2CST53TK/image-asset.png</image:loc>
      <image:title>2012 - Liang, G., He, J., Zhang, Y. (2012) Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol. 14(5):457-66.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693065799-NKS2NGGMBE8II6IM55OY/image-asset.png</image:loc>
      <image:title>2012 - Wu, H., and Zhang, Y. (2012). Early embryos reprogram DNA methylation in two steps. Cell Stem Cell 10(5):487-489.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693079120-QSZAA6YGFUQ11KI6VA3M/image-asset.png</image:loc>
      <image:title>2012 - Nabel, C.S., Jia, H., Ye, Y., Shen, L., Goldschmidt, H.L., Stivers, J.T., Zhang, Y., and Kohli, R.M. (2012). AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. Nat Chem Biol. 8(9):751-758</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693098353-3NWC09P1KD9Z23YW8HL3/image-asset.png</image:loc>
      <image:title>2012 - Yamaguchi, S., Hong, K., Liu, R., Shen, L., Inoue, A., Deip, D., Zhang, K., and Zhang, Y. (2012). Tet1 controls meiosis by regulating meiotic gene expression. Nature 492(7429):443–447.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499693111848-XZSAJMR3GBJ1I1PW6D6Z/image-asset.png</image:loc>
      <image:title>2012 - Inoue, A., Matoba, S., and Zhang, Y. (2012). Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation. Cell Res 22(12):1640-1649.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2011</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-20</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717016873-I8W8TMB430P9NPWZM2Z9/image-asset.png</image:loc>
      <image:title>2011 - Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.H., Ito, S., Yang, C., Wang, P., Xiao, M.T., Liu, L.X., Jiang, W.Q., Liu, J., Zhang, J.Y., Wang, B., Frye, S., Zhang, Y., Xu, Y.H., Lei, Q.Y, Guan, K.L., Zhao, S.M., Xiong, Y. (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketogluterate-dependent dioxygenases. Cancer Cell. 19(1):17-30.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717038199-I0JKC8ESHHL8UHFR97A4/image-asset.png</image:loc>
      <image:title>2011 - Nguyen, A.T., Xiao, B., Neppl, R.L., Kallin, E.M., Li, J., Chen, T., Wang, D.Z., Xiao, X., Zhang, Y. (2011) DOT1L regulates dystrophin expression and is critical for cardiac function. Genes and Development 25(3):263-74</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717050064-5KGFL26E160SSI5IE0SX/image-asset.png</image:loc>
      <image:title>2011 - He, J., Nguyen, A.T., Zhang, Y. (2011) KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 117(14):3869-3880.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717073132-KC32E9KBN8LROEO3IWK7/image-asset.png</image:loc>
      <image:title>2011 - Wu, H.*, D'Alessio, A.C.*, Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Sun, Y.E., Zhang, Y. (2011) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473(7347):389-393. (* authors contributed equally)</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717085169-YKIATV8IGETEJO24TYNC/image-asset.png</image:loc>
      <image:title>2011 - Wu, H., D'Alessio, A.C., Ito, S., Wang, Z., Cui, K., Zhao, K., Sun, Y.E., Zhang, Y. (2011) Genome-wide analysis of 5-hydroxymethylsytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes and Development 25(7):679-84.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717097631-9YUPNTTH60AC8KRX56SP/image-asset.png</image:loc>
      <image:title>2011 - Nguyen, A. T., Taranova, O., He, J. &amp; Zhang, Y. (2011) DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood 117(25):6912-6922.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717124589-2MG2FBZ15JDKBK4RXD8B/image-asset.png</image:loc>
      <image:title>2011 - Nguyen, A.T., and Zhang, Y. (2011). The diverse functions of Dot1 and H3K79 methylation. Genes and Development 25(13):1345-1358.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717111896-PC73C2NKSQY5WSLHB6FM/image-asset.png</image:loc>
      <image:title>2011 - Wu, H., and Zhang, Y. (2011). Tet1 and 5-hydroxymethylation: A genome-wide view in mouse embryonic stem cells. Cell Cycle 10(15):2428-2436.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717145794-YAIGGWWR40NQO9KRUIE9/image-asset.png</image:loc>
      <image:title>2011 - Wu, S.C., and Zhang, Y. (2011). Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability. J Biol Chem 286(32):28511-28519.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717161246-S928UJ3HGRG5HXMLVDG5/image-asset.png</image:loc>
      <image:title>2011 - Nguyen, A.T., He, J., Taranova, O., and Zhang, Y. (2011). Essential role of DOT1L in maintaining normal adult hematopoiesis. Cell Res 21(9):1370-1373.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717177045-7GP1VURCMY6WTLVO9C1C/image-asset.png</image:loc>
      <image:title>2011 - Ito, S.*, Shen, L.*, Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C., and Zhang, Y. (2011). Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333(6047):1300-1303. (* authors contributed equally)</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717195934-0LUE1WML8PUQ1JLLCVML/image-asset.png</image:loc>
      <image:title>2011 - Tao, Y., Neppl, R.L., Huang, Z.P., Chen, J., Tang, R.H., Cao, R., Zhang, Y., Jin, S.W., and Wang, D.Z. (2011). The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol 194(4):551-565.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717213120-W7BUTZSZQTQPEPZMLVME/image-asset.png</image:loc>
      <image:title>2011 - Inoue, A. and Zhang, Y. (2011). Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos. Science 334(6053):194.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717238150-W1YWLTKTM6WI4JGOIZM6/image-asset.png</image:loc>
      <image:title>2011 - Inoue, A., Shen, L., Dai, Q., He, C., and Zhang, Y. (2011). Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res 21(12):1670-1676.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1499717257539-H7QSR9NJFURUS5IDJIFD/image-asset.png</image:loc>
      <image:title>2011 - Wu, H. and Zhang, Y. (2011). Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25(23):2436-2452</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2010-and-earlier</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-22</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184025128-4HODB9BNXYPAU6ZMK6F3/image-asset.png</image:loc>
      <image:title>2010 and earlier - Okada, Y., Tateishi, K., Zhang, Y. (2010) Histone demethylase JHDM2A is involved in male infertility and obesity. Journal of Andrology 31(1):75-78.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184033710-TQSM7L5ILMNY7JK77TDI/image-asset.png</image:loc>
      <image:title>2010 and earlier - He, J. and Zhang, Y. (2010) Janus Kinase 2: An epigenetic 'writer' that activates leukemogenic genes. Journal of Molecular Cell Biology 2(5):231-233.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501183938953-DUQYWR92WEKY4QL1SQGI/pdf2.png</image:loc>
      <image:title>2010 and earlier - Okada, Y., Yamagata, K., Hong, K., Wakayama, T., Zhang, Y. (2010) A role for the elongator complex in zygotic paternal genome demethylation. Nature 463(7280):554-558</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184040486-MB7K79M3N2RANYVVYYER/image-asset.png</image:loc>
      <image:title>2010 and earlier - Yang, Y., Jiang, J, Stewart, D.M., Qi, S., Yamane, K., Li, J., Zhang, Y., Wong, J. (2010) AOF1 is a histone H3K4 demethylation posessing demethylation activity-independent repression function. Cell Research 20(3):276-287</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184045770-D50JXOCR1JD0VRRAVMUY/image-asset.png</image:loc>
      <image:title>2010 and earlier - An, J.Y., Kim, E.e-A., Jiang, Y., Zakrzewska, A., Kim, D.E., Lee, M.J., Mook-Jung, I., Zhang, Y., Kwon, Y.T. (2010) UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. PNAS 107(5):1912-1917.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184051434-NXFTOKQ2Y9DN14PCBV97/image-asset.png</image:loc>
      <image:title>2010 and earlier - Chen, H., Giri, N.C., Zhang, R., Yamane, K., Zhang, Y., Maroney, M., Costa, M. (2010) Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. JBC 285(10):7374-7383.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184083580-9BXW6EACOIY9QVF8D6ZX/image-asset.png</image:loc>
      <image:title>2010 and earlier - Liang, G., Taranova, O., Xia, K., Zhang, Y. (2010) Butyrate promotes iPS cell generation. JBC 285(33):25516-21.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184233694-I8LR3TAHVRMT7M528VYG/image-asset.png</image:loc>
      <image:title>2010 and earlier - Ito, S., D'Alessio, A.C., Taranova, O.V., Hong, K., Sowers, L.C., Zhang, Y. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466(7310):1129-1133.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184389798-9LVZU6OIO68KQ7HCXUNN/image-asset.png</image:loc>
      <image:title>2010 and earlier - Wu, S.C., Kallin, E.M. and Zhang, Y. (2010) Role of H3K27methylation in the regulation of lncRNA expression. Cell Research 20(10):1109-16.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184394917-TB7T9GRPN3I08903DDQC/image-asset.png</image:loc>
      <image:title>2010 and earlier - Wu, S.C. and Zhang, Y. (2010) Active DNA demethylation: many roads lead to Rome. Nature Reviews Molecular Cell Biology. 11(9):607-620.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501184401616-6QSI9Q64GRPPEHYWW9N4/image-asset.png</image:loc>
      <image:title>2010 and earlier - Tanaka, Y., Okamoto, K., Teye, K., Umata, T., Yamagiwa, N., Suto, Y., Zhang, Y., Tsuneoka, M. (2010)JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO Journal. 29(9):1510-22.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/implantation</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2018-08-03</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1502987062780-XSMB4LXA7JGPBNR91T7V/slide8.jpg</image:loc>
      <image:title>Development</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1502986967917-JIVHHQLAW54AZBQ0LP33/File_000+%281%29.jpeg</image:loc>
      <image:title>Development</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1502987014779-NNMKSL45D1SADOY3WA97/slide4.jpg</image:loc>
      <image:title>Development</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/news-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-08-14</lastmod>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2017-2</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-16</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127573609-XQ34YOWIFOS2K6U5X9LL/pdf.png</image:loc>
      <image:title>2017 - Wu, X., Inoue, A., Tsukasa Suzuki, Zhang, Y., (2017) Simultaneous mapping of active DNA demethylation and sister chromatid exchange in single cells. Genes Dev. 31(5):511-523</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1527257862134-EB9A75637RWDGOA2L26Z/image-asset.png</image:loc>
      <image:title>2017 - Renchao Chen, Xiaoji Wu, Lan Jiang, Yi Zhang (2017) Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity. Cell Reports 18(13):3227-3241</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501606253971-U2BN6EB5KB9KZ7ZMXZUF/pdf.png</image:loc>
      <image:title>2017 - Wu, X. and Zhang, Y. (2017)TET-mediated active DNA demethylation: mechanism, function and beyond. Nature Review Genetics 18(9):517-534</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501607006142-GRZCTR2EPGZ6KLXKHC8W/image-asset.png</image:loc>
      <image:title>2017 - Inoue, A., Jiang, L., Lu, F., Suzuki, T., &amp; Zhang, Y. (2017) Maternal H3K27me3 controls DNA methylation-independent imprinting. Nature 547(7664):419-424</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1507665370224-L2K5D428NWKEZT3DX8A8/pdf.png</image:loc>
      <image:title>2017 - Chen-Cheng Lee, Shih-Huan Peng Li Shen, ..., Yu-Ting Yan, Yi Zhang, Li-Jung Juan (2017) The Role of N-a-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Molecular Cell. 68(1):89–103</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1509982164844-F7IYBIDDRQNFJM8Z0BQK/pdf.png</image:loc>
      <image:title>2017 - Azusa Inoue, Lan Jiang, Falong Lu, and Yi Zhang (2017) Genomic imprinting of Xist by maternal H3K27me3. Genes Dev 31(19):1927-1932.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/addiction</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2018-10-01</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501010106223-WQPVWYJ9SRMOKA2OBUOF/VTA+10x</image:loc>
      <image:title>Addiction</image:title>
      <image:caption>Midbrain micrograph showing VTA dopamine neurons (green), MeCP2 (red) and nuclei (blue)</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501600294486-LA37WB59C5SJMI73GPUH/addictbrain</image:loc>
      <image:title>Addiction</image:title>
      <image:caption>Micrograph of hippocampal neurons (green), and nuclei (blue)</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501010196148-FMPHUTJQ0VUO9AQ617QU/CAV+HA+Neurons</image:loc>
      <image:title>Addiction</image:title>
      <image:caption>NAc-projecting VTA neurons (green), VTA dopamine neurons (red), and nuclei (blue)</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/technology</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-23</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1503520719467-VHWKVI6V6VGSQ4C5ARL7/Lab-image-3-liDNase.jpg</image:loc>
      <image:title>Technology</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1503520690273-WY4FWH6DV6QSW3E3B6XX/mice.jpg</image:loc>
      <image:title>Technology</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1501768511532-CDTVJRD8OAI9X9SH7JHG/Lab-image-Single-cell-analysis.jpg</image:loc>
      <image:title>Technology</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/alumni-2</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-10-12</lastmod>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/reagent-request</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2018-03-30</lastmod>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2018</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-16</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127648838-UZBJR06C45P4VTAS8GYG/pdfsmall.png</image:loc>
      <image:title>2018 - Kim H, Kim D, Choi SA, Kim CR, Oh SK, Pyo KE, Kim J, Lee SH, Yoon JB, Zhang Y, Baek SH (2018) KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway PNAS 115(46):11766-11771</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127669445-0L5G764XNSP39HEK0BY1/pdfsmall.png</image:loc>
      <image:title>2018 - Inoue A, Chen Z, Yin Q, Zhang Y (2018) Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells. Genes &amp; Development (32):1525-1536</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127680556-18JT00CQGUFADPYZ1F6B/pdfsmall.png</image:loc>
      <image:title>2018 - Djekidel MN, Inoue A, Matoba S, Suzuki T, Zhang C, Lu F, Jiang L, Zhang Y (2018) Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Reports; 23(7):1939-1947</image:title>
      <image:caption>Djekidel MN, Inoue A, Matoba S, Suzuki T, Zhang C, Lu F, Jiang L, Zhang Y (2018) Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Reports; 23(7):1939-1947</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127693214-DHUK0OR5EGKMHXMJSSSX/pdfsmall.png</image:loc>
      <image:title>2018 - Matoba S, Wang H, Jiang L, Lu F, Iwabuchi K, Wu X, Inoue K, Yang L, Press W, Lee J, Ogura A, Shen L, and Zhang Y. (2018) Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts PostImplantation Development. Cell Stem Cell 23(3): 343-354</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127709440-BMH4IWAX0I5RUD2BEMLP/pdfsmall.png</image:loc>
      <image:title>2018 - Matoba S, and Zhang Y (2018) Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications. Cell Stem Cell 23(4):471-485</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2009</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
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    <priority>0.75</priority>
    <lastmod>2021-12-23</lastmod>
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    <lastmod>2021-12-28</lastmod>
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    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
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    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
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    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
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      <image:title>2004 - Umlauf, D., Goto, Y., Cao, R., Cerqueira, F., Zhang, Y., and Feil, R. (2004). Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nature Genetics 36(12):1296-1300.</image:title>
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      <image:title>2004 - Wang, H.-B., Wang, L., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R. S., and Zhang, Y. (2004) Role of H2A ubiquitination in Polycomb silencing. Nature 431(7010):873-878.</image:title>
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      <image:title>2004 - Zhang, Y. (2004). Molecular Biology: No exception to reversibility. Nature 431(7009):637-639.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2004 - Bender, L.B., Cao, R., Zhang, Y., and Strome, S. (2004) The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in the C.elegans. Curr Biol 14(18):1639-1643.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2004 - Cao, R. and Zhang, Y. (2004). SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 15(1):57-67.</image:title>
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      <image:title>2004 - Wang, L., Brown, J. L., Cao, R., Zhang, Y., Kassis, J. A., and Jones, R. S. (2004). Hierarchical recruitment of Polycomb-group silencing complexes. Mol Cell 14(5):637-646.</image:title>
    </image:image>
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      <image:title>2004 - Cao, R. and Zhang, Y. (2004). The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Gene. Dev. 14(2):155-164.</image:title>
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      <image:title>2004 - Fang, J., Wang, H-B., and Zhang, Y. (2004). Purification of histone methyltransferases from HeLa cells. Methods in Enzymol. 377, 213-226.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2003</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Zhang, Y. (2003). Transcriptional regulation by histone ubiquitination and deubiquitination. Genes Dev 17(22):2733-2740.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Wang, H-B., An W. Cao, R., Xia, L., Erdjument-Bromage, H., Chatton, B., Tempst, P., Roeder, R. and Zhang, Y. (2003). mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12(2):475-487.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Min, J., Zhang, Y. Xu, R.-M. (2003). Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev 17(15):1823-1828.</image:title>
    </image:image>
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      <image:title>2003 - Im, H., Park, C., Feng, Q., Johnson, K.D., Kiekhaefer, C.M., Choi, K., Zhang, Y., Bresnick, E. (2003). Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain. J Biol Chem 278(20):18346-18352.</image:title>
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      <image:title>2003 - Plath, K., Fang, J., Mlynarczyk-Evans, S. K., Cao, R., Worringer, K. A., Wang, H., de la Cruz, C. C., Otte, A., Panning, B., Zhang, Y. (2003). Role of histone H3 lysine 27 methylation in X-inactivation. Science 300(5616):131-135.</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Min, J., Feng, Q., Li, Z., Zhang, Y. Xu, R.-M. (2003). Structure of the catalytic domain of human Dot1L, a non-SET domain nucleosomal histone methyltransferase. Cell 112(5): 711-723.</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Ramsden, D., and Zhang, Y. (2003). Everything is E(Z): Linking histone methylation to B cell development. Nature Immunology 4(2):101-103.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2003 - Wood, A., Krogan, N. J., Dover, J., Schneider, J. Heidt, J., Boateng, M. A., Dean, K., Zhang, Y., Greenblatt, J. F., Johnston, M., and Shilatifard, A. (2003). Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol. Cell 11(1): 267-274.</image:title>
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      <image:title>2003 - Feng, Q., and Zhang, Y. (2003). The NuRD complex: linking histone modification to nucleosome remodeling. In “Protein Complexes that Modify Chromatin” (Ed. J. L. Workman). Current Topics in Microbiology and Immunology 274, 269-290.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2002</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2002 - Iratni, R., Yan, Y.-T., Chen, C., Ding, J., Zhang, Y., Price, S. M., Reinberg, D., Shen, M. M. (2002). Inhibition of excess Nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science 298(5600):1996-1999.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2002 - Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R.S., Zhang, Y. (2002). Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298(5595):1039-1043.</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2002 - Ng, H.-H., Rui-Ming Xu, Zhang, Y., Struhl, K. (2002). Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3-lysine 79. J Biol Chem 277(38):34655-34657.</image:title>
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      <image:title>2002 - Fang, J., Feng, Q., Ketel, C.S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J.A., Zhang, Y. (2002). Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol 12(13):1086-1099.</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2002 - Feng, Q., Wang, H., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Struhl, K., and Zhang, Y. (2002). Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol 12(12):1052-1058.</image:title>
    </image:image>
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      <image:title>2002 - Ng, H.-H., Feng, Q., Wang, H., Erdjument-Bromage, H., Tempst, P., Zhang, Y., and Struhl, K. (2002). Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-1527.</image:title>
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      <image:title>2002 - Yang, L., Xia, L., Wu, D. Y., Wang, H.-B., Chansky, H. A., Schubach, W. H., Hickstein, D. D., and Zhang, Y. (2002). Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21(1):148-152.</image:title>
    </image:image>
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      <image:title>2002 - Kuzmichev, A., Zhang, Y., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. (2002). Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33ING1. Mol. Cell. Biol. 22(3):835-848.</image:title>
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      <image:title>2002 - Feng, Q., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., and Zhang, Y. (2002). Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol. Cell. Biol. 22(2):536-546.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2001</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2001 - Wang, H-B., Cao, R., Xia, L., Erdjument-Bromage, H., Borchers, C., Tempst, P., and Zhang, Y. (2001). Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol. Cell 8(6):1207-1217.</image:title>
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    <image:image>
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      <image:title>2001 - Zhang, Y. and Reinberg, D. (2001). Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes &amp; Dev 15(18):2343-2360.</image:title>
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      <image:title>2001 - Wang, H-B., and Zhang, Y. (2001). Mi2, an autoantigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor. Nucleic Acids Res. 29(12):2517-2521.</image:title>
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      <image:title>2001 - Wang, H-B., Huang, Z.-Q., Li, X., Feng, Q., Erdjument-Bromage, H., Strahl, B.D., Briggs, S., Allis, D.C., Wong, J., Tempst, P., and Zhang, Y. (2001). Methylation of histone H4 at arginine 3 facilitates transcriptional activation by nuclear hormone receptor. Science 293(5531):853-857.</image:title>
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    <image:image>
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      <image:title>2001 - Li, X., and Zhang, Y. (2001). Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression. Gene 268(1-2):77-85.</image:title>
    </image:image>
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      <image:title>2001 - Lai, A., Kennedy, B.K., Barbie, D.A., Bertos, N.R., Yang, X.J. Theberge, M.-C., Tsai, S-C., Seto, E., Zhang, Y., Kuzmichev, A. et al. (2001). RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of Retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol. Cell. Biol. 21(8):2918-2932.</image:title>
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      <image:title>2001 - Feng, Q. and Zhang, Y., (2001). The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes &amp; Dev, 15(7):827-832.</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2000-and-earlier</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-28</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111661848-HCP7A74J8XC06QTNH8BB/pdfsmall.png</image:loc>
      <image:title>2000 and Earlier - Ng, H-H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., ad Bird, A. (1999). MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genetics 23(1):58-61.</image:title>
    </image:image>
    <image:image>
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      <image:title>2000 and Earlier - Zhang, Y., Ng, H-H., Erdjument-Bromage, H., Tempst, P., Bird, A., and Reinberg, D. (1999). Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes &amp; Dev. 13(15):1924-1935.</image:title>
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      <image:title>2000 and Earlier - Zhang, Y., LeRoy, G., Seelig, H.-P., Lane, W., and Reinberg, D. (1998). The dermatomyositis-specific autoantigen Mi2 is a component of a protein complex containing histone deacetylase and nucleosome remodeling activities. Cell 95(2):279-289.</image:title>
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      <image:title>2000 and Earlier - Sun, X., Zhang, Y., Cho, H., Rickert, P., Lees, E., Lane, W., and Reinberg, D. (1998). NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol Cell 2(2):213-222.</image:title>
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    <image:image>
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      <image:title>2000 and Earlier - Zhang, Y., Sun, Z. W., Iratni, R., Erdjument-Bromage, H., Tempst, P., Hampsey, M., and Reinberg, D. (1998). SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell 1(7):1021-1031.</image:title>
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      <image:title>2000 and Earlier - Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. (1997). Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89(3):357-364.</image:title>
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    <image:image>
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      <image:title>2000 and Earlier - Zhang, Y., and Epstein, L. M. (1996). Cloning and characterization of satellite 2 hammerheads from a diverse set of caudate amphibians. Gene 172(2):183-190.</image:title>
    </image:image>
    <image:image>
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      <image:title>2000 and Earlier - Coats, S. R., Zhang, Y., and Epstein, L. M. (1994). Transcription of satellite 2 from the newt is driven by a snRNA type of promoter. Nucleic Acids Res. 22(22):4697-4704.</image:title>
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    <image:image>
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      <image:title>2000 and Earlier - Pabon-Pena, L.M., Zhang, Y., and Epstein, L. M. (1991). Newt satellite 2 transcripts self-cleave by using an extended hammerhead structure. Mol. Cell. Biol. 11(12):6109-6115.</image:title>
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  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2019</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-16</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127709440-BMH4IWAX0I5RUD2BEMLP/pdfsmall.png</image:loc>
      <image:title>2019 - Zhang W, Chen Z, Yin Q, Zhang D, Racowsky C, Zhang Y (2019) Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula Genes &amp; Development 33(7-8):382-387</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127709440-BMH4IWAX0I5RUD2BEMLP/pdfsmall.png</image:loc>
      <image:title>2019 - Chen Z, Zhang Y(2019) Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development. Nature genetics, 51(6): 947-951</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1544127693214-DHUK0OR5EGKMHXMJSSSX/pdfsmall.png</image:loc>
      <image:title>2019 - Tuesta LM, Djekidel MN, Chen R, Lu F, Wang W, Sabatini BL, Zhang Y (2019) In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function Nature Communications 10(1), 2508</image:title>
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      <image:title>2019 - Fu X, Wu X, Djekidel MN, Zhang Y (2019) Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells. Nature Cell Biology 21(7): 835-844</image:title>
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      <image:title>2019 - Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG (2019) MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition. Cell Reports. 28(2):472–485</image:title>
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      <image:title>2019 - Bhattacherjee A, Djekidel MN, Chen R, Chen W, Tuesta L, Zhang Y (2019) Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction. Nature Communications. 10(1), 4169</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579112494689-MDSPP4TG9E1TJQZOFRNC/pdfsmall.png</image:loc>
      <image:title>2019 - Chen Z, Yin Q, Inoue A, Zhang C, Zhang Y (2019) Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting inextraembryonic cells. Sci Adv. 5(12)</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/neuro-group</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2019-09-13</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1566765924615-OS3CYYJYVDWRP8AJMTYT/Hypothalamous_scaled.jpg</image:loc>
      <image:title>Neuro Group - Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity</image:title>
      <image:caption>Chen et al., 2017, Cell Reports 18, 3227–3241 -) Download GEO data - )Explore data</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1566765161189-7NK2JBS6XSRGUT1U1UXF/PFC.png</image:loc>
      <image:title>Neuro Group - Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction</image:title>
      <image:caption>Bhattacherjee et al., 2019, Nature Communications - Download GEO data. - Explore data</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1566765890562-VMTM6AYW6FSEMYEVGNFP/Gmeb1.jpg</image:loc>
      <image:title>Neuro Group - In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function.</image:title>
      <image:caption>Tuesta et al., 2019. Nature Communications 10(1), 2508 -) Download GEO data .</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1568403598765-GXVRDOOGLSW1QX346GQY/NAC_project.jpg</image:loc>
      <image:title>Neuro Group - Transcriptional and functional characterization of nucleus accumbens neurons</image:title>
      <image:caption>Ongoing project</image:caption>
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  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2020</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2021-12-16</lastmod>
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      <image:title>2020 - Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi A, Zhang Y (2020) The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression Genes Dev 34:1-13</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579188196504-JOPHSV9OT6PPBR09M77M/pdfsmall.png</image:loc>
      <image:title>2020 - Chen Z, Zhang Y (2020) Role of Mammalian DNA Methyltransferases in Development Annu Rev Biochem 89:135-158</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1592225769691-RTS5TH1ZAB27SGF0T9RI/pdfsmall.jpg</image:loc>
      <image:title>2020 - Fu X, Djekidel MN, Zhang Y (2020) A transcriptional roadmap for 2C-like–to–pluripotent state transition Sci Adv . 6(22)</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1592225769691-RTS5TH1ZAB27SGF0T9RI/pdfsmall.jpg</image:loc>
      <image:title>2020 - Chen Z, Zhang Y (2020) Maternal H3K27me3-dependent Autosomal and X Chromosome Imprinting Nat Rev Genet 21:555-571</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1592225769691-RTS5TH1ZAB27SGF0T9RI/pdfsmall.jpg</image:loc>
      <image:title>2020 - Fu X, Zhang C, Zhang Y (2020) Epigenetic Regulation of Mouse Preimplantation Embryo Development Curr Opin Genet Dev 64:13-20</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2020-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-06-15</lastmod>
    <image:image>
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      <image:title>2020 (Copy) - Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi A, Zhang Y (2020) The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes Dev 34: 1-13</image:title>
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      <image:title>2020 (Copy) - Chen Z, Zhang Y (2020) Role of Mammalian DNA Methyltransferases in Development. Annu Rev Biochem 89: 2.1-2.24</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2021</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-12</lastmod>
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      <image:title>2021 - Chen Z, Djekidel MN, Zhang Y (2021) Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos Nat Genet 53(4):551-563</image:title>
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      <image:title>2021 - Chen R, Blosser TR, Djekidel MN, Hao J, Bhattacherjee A, Chen W, Tuesta LM, Zhuang X, Zhang Y (2021) Decoding molecular and cellular heterogeneity of mouse nucleus accumbens Nat Neuroscience 24:1757–1771</image:title>
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      <image:title>2021 - Chu C,  Zhang W, Kang Y, Si C, Ji W, Niu Y, Zhang Y (2021) Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta Dev Cell    56(20):2826-2840</image:title>
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      <image:title>2021 - Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y (2021) eccDNAs are apoptotic products with high innate immunostimulatory activity Nature 599:308–314</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1592225769691-RTS5TH1ZAB27SGF0T9RI/pdfsmall.jpg</image:loc>
      <image:title>2021 - Chen Z, Xie Z, Zhang Y (2021) DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development Development 148(24)</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2022</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-01-16</lastmod>
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      <image:title>2022 - Gao Y, Duque-Wilckens N, Aljazi MB, Moeser AJ, Mias GI, Robison AJ, Zhang Y, He J (2022) Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors iScience 25(2)</image:title>
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      <image:title>2022 - Zhang C, Wang M, Li Y, Zhang Y (2022) Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition Science Advances 8(5)</image:title>
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      <image:title>2022 - Xie Z, Zhang W, Zhang Y (2022) Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation Cell Reports 38(8)</image:title>
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      <image:title>2022 - Chen R, Liu Y, Djekidel MN, Chen W, Bhattacherjee A , Chen Z, Scolnick E, Zhang Y (2022) Cell type–specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis Science Advances 8(9)</image:title>
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      <image:title>2022 - Zhang W, Zhang Y (2022) TARSII and CARSII: Two approaches for SNP-independent identification of germline differentially methylated regions in mammals STAR Protocols (3)2</image:title>
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      <image:title>2022 - Zhao Z, Han X, Chen R, Liu Y, Bhattacherjee A, Chen W, Zhang Y (2022) A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction Science Advances 8(32)</image:title>
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      <image:title>2022 - Zhang C, Chen R, Zhang Y (2022) Accurate inference of genome-wide spatial expression with iSpatial Sciences Advances 8(34)</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579120391530-PNRU6KI5E5C0ZLSPMY3F/pdfsmall.png</image:loc>
      <image:title>2022 - Wang M, Chen Z, Zhang Y (2022) CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos The EMBO Journal 41(22)</image:title>
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      <image:title>2022 - Bhattacherjee A, Zhang C, Watson B, Djekidel MN, Moffit J, Zhang Y (2022) Understanding prefrontal cortex functions by decoding its molecular, cellular and circuit organization bioRxiv</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/neuro-group/nac/scrnaseq</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-02-17</lastmod>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/neuro-group/nac/merfish</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-02-17</lastmod>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2023</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-01-16</lastmod>
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      <image:title>2023 - Liu Y, Zhao Z, Xie G, Chen R, Zhang Y (2023) A molecularly distinct accumbal-to-lateral hypothalamic circuit modulates food seeking and consumption bioRxiv</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579120391530-PNRU6KI5E5C0ZLSPMY3F/pdfsmall.png</image:loc>
      <image:title>2023 - Zhang C, Zhang Y (2023) Start of life controlled by poly(A) tail-mediated remodeling Trends in Genetics 39(5):340-341</image:title>
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      <image:title>2023 - Wang Y, Meng W, Zhang Y (2023) Purification, full-length sequencing and genomic origin mapping of eccDNA Nature Protocols 18(3):683-699</image:title>
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      <image:title>2023 - Bhattacherjee A, Zhang C, Watson B, Djekidel MN, Moffitt J, Zhang Y (2023) Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain Nature Neuroscience 26(11):1880-1893</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2024</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-01-16</lastmod>
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      <image:title>2024 - Liu Y, Wang Y, Zhao Z, Xie G, Zhang C, Chen R, Zhang Y (2024) A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis. Nature Metabolism 6(8):1616-1631</image:title>
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      <image:title>2024 - Zhou C, Wang M, Zhang C, Zhang Y (2024) The transcription factor GABPA is a master regulator of naïve pluripotency. bioRxiv</image:title>
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      <image:title>2024 - Wang Y, Zhang W, Zhang C, Van HT, Seino T, Zhang Y (2024) Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice. bioRxiv</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2025</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-01-06</lastmod>
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      <image:title>2025 - Wang Y, Zhang W, Zhang C, Van HT, Seino T, Zhang Y (2025) Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice. Cell Research 35(1):45–58</image:title>
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      <image:title>2025 - Zhou C, Wang M, Zhang C, Zhang Y (2025) The transcription factor GABPA is a master regulator of naive pluripotency. Nature Cell Biology 27(1): 48–58</image:title>
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      <image:title>2025 - Liu Y, Wang Y, Xie G, Yang Q, Bhattacherjee A, Zhang C, Zhang Y (2025) A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference. Science Advances 11(17)</image:title>
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      <image:title>2025 - Ren X, Wang Y, Zhang Y ( 2025) Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. Cell Discovery 11(1):56</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579120391530-PNRU6KI5E5C0ZLSPMY3F/pdfsmall.png</image:loc>
      <image:title>2025 - Sun N, Lin CH, Li MY, Wang Y, Chen D, Ren X, Zhang F, Zhang Y (2025) Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function Nature Aging 5(8):1510-1527</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579118938983-KSMRCU0MI88J62DCFJ3G/pdfsmall.png</image:loc>
      <image:title>2025 - Hagihara Y, Zhang C, Zhang Y (2025) Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity. Nature Genetics 57(9):2250-2263</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.zhanglab.tch.harvard.edu/2026</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-04-02</lastmod>
    <image:image>
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      <image:title>2026 - Xie G, Liu Y, Qi X, Bhattacherjee A, Zhang C, Zhang Y (2026) A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain. Nature Communications 17(2134)</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1579111586536-Y3R05DWINJ75NLIU1BCL/pdf.png</image:loc>
      <image:title>2026 - Yao J, Wang Y, Zhang Y (2026) Cooperative Interaction Between IL-4 Signaling and FLT3 in Multipotent Progenitors Restore Lymphopoiesis in Inflammation and Aging. bioRxiv</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/592f089eebbd1a8c7a84f0a0/1592225769691-RTS5TH1ZAB27SGF0T9RI/pdfsmall.jpg</image:loc>
      <image:title>2026 - Yang Q, Jiang S, Wang B, Zhang Y (2026) NFYA regulates two sequential genome-wide transcriptional activation events during oocyte-to-embryo transition. bioRxiv</image:title>
    </image:image>
  </url>
</urlset>

